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CISCO security laboratory exercise
Švec, Martin ; Hajný, Jan (oponent) ; Pelka, Tomáš (vedoucí práce)
The main purpose of this diploma thesis is to become familiar with the principles and technical solutions regarding security components of Cisco company and configure assigned system according to valid rules of security. In introduction are explained the reasons for networks security solutions. This work also analyses different kinds of security weaknesses which include deficiencies of networks protocols and also the attacks from hackers. The principle of firewall is described and also its particular types. This work is focused on explanation and classification of PIX firewall, which has dominant role in the field of network security. The other equipments of Cisco, which are improving the level of security, are also mentioned. The practical part of this diploma thesis is composed of networks connections and configuration of system consisting of router, PIX firewall and switch. It also includes the detailed procedure and description of configuration of network equipments. The focus is put on minimalization of threats and elimination of DoS attacks.
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New regulatory mechanisms of microtubule nucleation
Černohorská, Markéta ; Dráber, Pavel (vedoucí práce) ; Binarová, Pavla (oponent) ; Hašek, Jiří (oponent)
SOUHRN Mikrotubuly jsou dynamické cytoskeletální polymery, které jsou nepostradatelné pro základní buněčné aktivity, jako je udržení buněčného tvaru, dělení, prostorová distribuce organel, migrace a transport váčků. Přestože je nukleace mikrotubulů z komplexů -tubulinu základním krokem ve formaci mikrotubulárního cytoskeletu, signální dráhy regulující nukleaci z centrosomů, jsou u interfázních buněk neznámé. V odborných studiích jsem se koncentrovali na tyto regulační mechanismy. V savčích buňkách je -tubulin kódován dvěma geny. Ukázali jsme, že -tubulin 2 je schopen zastoupit -tubulin 1 v nukleaci mikrotubulů. Navíc jsme zjistili, že -tubuliny jsou různě exprimovány během časné embryogeneze a v dospělých tkáních u myší. Na základě těchto nálezů navrhujeme, že savčí -tubuliny jsou v otázce nukleace mikrotubulů funkčně rovnocenné. Aktivace žírných buněk vede k formaci protruzí, které jsou tvořeny mikrotubuly v závilosti na vápníku. Objevili jsme dva signální proteiny, PIX a GIT1, které interagují s -tubulinem a lokalizují se na centrozomu. GIT1 je fosforylován na tyrosinu u aktivovaných žírných buněk a interaguje s -tubulinem v závilosti na vápníku. Navrhujeme novou signální dráhu pro reorganizaci mikrotubulů u žírných buněk, ve které na tyrozinech-aktivované GIT1 a PIX spolupracují s vápníkovou...
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CISCO security laboratory exercise
Švec, Martin ; Hajný, Jan (oponent) ; Pelka, Tomáš (vedoucí práce)
The main purpose of this diploma thesis is to become familiar with the principles and technical solutions regarding security components of Cisco company and configure assigned system according to valid rules of security. In introduction are explained the reasons for networks security solutions. This work also analyses different kinds of security weaknesses which include deficiencies of networks protocols and also the attacks from hackers. The principle of firewall is described and also its particular types. This work is focused on explanation and classification of PIX firewall, which has dominant role in the field of network security. The other equipments of Cisco, which are improving the level of security, are also mentioned. The practical part of this diploma thesis is composed of networks connections and configuration of system consisting of router, PIX firewall and switch. It also includes the detailed procedure and description of configuration of network equipments. The focus is put on minimalization of threats and elimination of DoS attacks.
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